Along with Full House, Perfect Strangers was one of the hits that was part of ABC’s TGIF line-up in the 80s and early 90s. As with most sitcoms, the series was filmed in Hollywood but was set in Chicago.
In the first two seasons, a building in Los Angeles was used for establishing shots. In an odd change, the building had it’s upper floors demolished, leaving only the 1st floor intact. Lindsay from IAMNOTASTALKER has an excellent article about this building if you want to check it out.
Starting in season 3, the producers selected an apartment building in Chicago to use for establishing shots. While this apartment has changed a bit over the years, the building is still recognizable.
The Opening Credits
The opening credits that started in season 2 of Perfect Strangers feature the cousins in a number of locations around Chicago. These opening credits begin with the cousins on a tour boat cruising down the Chicago River.
The cousins are also seen approaching Wrigley Field to attend a Chicago Cubs game. Then the famous red Wrigley Field sign is prominently featured.
The last scene of the opening credits feature the cousins ascending from the subway and heading towards the Chicago Theatre.